HER-2 profiling and targeting in prostate carcinoma

Soluble HER-2 in Patients with Head and Neck Squamous Cell Carcinoma

Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters.   Materials and Methods: Peripheral blood samples were obtained ...

HER-3 expression in HER-2-amplified breast carcinoma

AIM OF THE STUDY To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC). MATERIAL AND METHODS In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues. RESULTS Higher HER-3 status if estimated b...

Breast Carcinoma; Human Epidermal Growth Factor Receptor-2 (HER-2) and Grading Correlation

Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlat...

Targeting HER-2/Neu in serous endometrial cancer: A review

Serous endometrial cancer is a clinically aggressive type of uterine cancer, responsible for a disproportionate incidence of advanced stage disease, recurrences and deaths. Serous endometrial cancers are characterized by alteration of p53, STK15, p16, and HER2. The purpose of this review is to describe the current understanding of the role of the HER-2/neu pathway in the carcinogenesis of serou...

Targeting HER-2 Signaling Network: Implication in Radiation Response